Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade.

doi:10.1038/sj.onc.1201784

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Article

Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade.

Oncogene - 1 May 1998

Oldham S M, Cox A D, Reynolds E R, Sizemore N S, Coffey R J, Der C J

Abstract excerpt

Src transformation of NIH3T3 mouse fibroblasts has been shown to be dependent on Ras function. Since we recently showed that the signaling pathways that mediate Ras transformation of RIE-1 rat intestinal epithelial cells are distinct from those that cause Ras transformation of fibroblasts, we uti...

Topics

Alkyl and Aryl Transferases
Animals
Calcium-Calmodulin-Dependent Protein Kinases
Cell Transformation, Neoplastic
Cells, Cultured
Enzyme Inhibitors
Epithelial Cells
ErbB Receptors
Farnesyltranstransferase
Genes, ras
Genes, src
Methionine
Mutation
Proto-Oncogene Proteins c-raf
Rats
Up-Regulation

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Open in PubMed

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PMID: 9632133
DOI: 10.1038/sj.onc.1201784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9632133-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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