Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line.

Cancer research - 1 May 1991

Vanhaesebroeck B, Van Bladel S, Lenaerts A, Suffys P, Beyaert R, Lucas R, Van Roy F, Fiers W

Abstract excerpt

From the murine fibrosarcoma cell line L929s, which is sensitive to tumor necrosis factor (TNF)-mediated cell lysis, two discrete types of TNF-resistant variants were derived by TNF selection. Cells of the first type (named L929r1) were not sensitized to TNF cytotoxicity by cotreatment with either inhibitors of protein or RNA synthesis, or gamma-interferon, despite the presence of a functional gamma-interferon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Phenotype
Share to Drug Screening Assays, Antitumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to TNF gene

Share to Receptors, Cell Surface

Share to Time Factors

Share to Tumor Cells, Cultured

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 1849793

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line.PMID 1849793Read ↗

Autocrine tumor necrosis factor (TNF) and lymphotoxin (LT) alpha differentially modulate cellular sensitivity to TNF/LT-alpha cytotoxicity in L929 cells.Semantic proximity Read ↗

Resistance to tumor necrosis factor induced apoptosis in vitro correlates with high metastatic capacity of cells in vivo.Semantic proximity Read ↗

Selection of tumor cell variants for resistance to tumor necrosis factor also induces a form of pleiotropic drug resistance.Semantic proximity Read ↗

Three distinct cell phenotypes of induced-TNF cytotoxicity and their relationship to apoptosis.Semantic proximity Read ↗

Identification of two U937 cell sublines exhibiting different patterns of response to tumour necrosis factor.Semantic proximity Read ↗

Apoptosis in a Fas-resistant, T-cell receptor-sensitive human leukaemic T-cell clone.Semantic proximity Read ↗

Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes.Semantic proximity Read ↗

Beta-actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death.Semantic proximity Read ↗

Acquired resistance to reoviral oncolysis in Ras-transformed fibrosarcoma cells.Semantic proximity Read ↗

Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.Semantic proximity Read ↗

Selection for Drug Resistance Results in Resistance to Fas-Mediated ApoptosisSemantic proximity Read ↗

In vivo tumorigenicity and in vitro sensitivity to tumor-necrosis-factor alpha mediated killing of c-Ha-ras-transformed cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.