Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line.

Article

Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line.

Cancer research - 1 May 1991

Vanhaesebroeck B, Van Bladel S, Lenaerts A, Suffys P, Beyaert R, Lucas R, Van Roy F, Fiers W

Abstract excerpt

From the murine fibrosarcoma cell line L929s, which is sensitive to tumor necrosis factor (TNF)-mediated cell lysis, two discrete types of TNF-resistant variants were derived by TNF selection. Cells of the first type (named L929r1) were not sensitized to TNF cytotoxicity by cotreatment with eithe...

Topics

Animals
Drug Screening Assays, Antitumor
Fibrosarcoma
Mice
Phenotype
Receptors, Cell Surface
Receptors, Tumor Necrosis Factor
Time Factors
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.