v-Src activates both protein kinase C-dependent and independent signaling pathways in murine fibroblasts.

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Article

v-Src activates both protein kinase C-dependent and independent signaling pathways in murine fibroblasts.

Oncogene - 1 Jun 1991

Qureshi S A, Joseph C K, Rim M, Maroney A, Foster D A

Abstract excerpt

Activating the protein-tyrosine kinase activity of v-Src rapidly induced expression of the two 'primary response' genes, TIS10 and Egr-1, in Balb/c 3T3 cells. Depleting cells of protein kinase C (PKC) by prolonged exposure to 12-O-tetradecanoylphorbol 13-acetate (TPA), blocked v-Src-induced TIS10...

Topics

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
Animals
Antibiotics, Antineoplastic
Cell Line
DNA-Binding Proteins
Early Growth Response Protein 1
Enzyme Activation
Fibroblasts
Gene Expression
Genes, src
Immediate-Early Proteins
Isoquinolines
Mice
Mice, Inbred BALB C
Phenotype
Phosphorylation
Piperazines
Protein Kinase C

Source

Open in PubMed

Identifiers

PMID: 2067850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2067850-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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