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Article

Direct transforming activity of TGF-beta on rat fibroblasts.

International journal of cancer - 29 Mar 1995

Vossbeck H, Strahm B, Höfler P, Bauer G

Abstract excerpt

Treatment of NRK 536 fibroblasts with EGF and transforming growth factor type beta (TGF-beta) is known to lead to the reversible induction of the transformed phenotype in a large percentage of cells. Maintenance of the transformed state is dependent on the continuous presence of the cytokines. Here we show that treatment of these cells with TGF-beta alone leads to the formation of a small percentage of colonies,...

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Share to Cells, Cultured
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7705938
DOI: 10.1002/ijc.2910610116

Genes

NRK
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Direct transforming activity of TGF-beta on rat fibroblasts.PMID 7705938Read ↗

Expression of the TGF alpha integral membrane precursor induces transformation of NRK cells.Semantic proximity Read ↗

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Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects.Semantic proximity Read ↗

Sensitivity of transformed fibroblasts for intercellular induction of apoptosis is determined by their transformed phenotype.Semantic proximity Read ↗

Role of TGF-beta in EGF-induced transformation of NRK cells is sustaining high-level EGF-signaling.Semantic proximity Read ↗

Expression of transfected transforming growth factor alpha induces a motile fibroblast-like phenotype with extracellular matrix-degrading potential in a rat bladder carcinoma cell line.Semantic proximity Read ↗

Transformation of rodent fibroblasts by herpes simplex virus: presence of morphological transforming region 1 (MTR 1) is not required for the maintenance of the transformed state.Semantic proximity Read ↗

Transforming growth factor beta 1 suppresses transformation in hepatocytes by regulating alpha 1 beta 1 integrin expression.Semantic proximity Read ↗

Revertants of v-fos-transformed rat fibroblasts: suppression of transformation is dominant.Semantic proximity Read ↗

Reversion by deletion of transforming oncogene following interferon-beta and retinoic acid treatment.Semantic proximity Read ↗

Oncogenic signal-induced ability to enter S phase in the absence of anchorage is the mechanism for the growth of transformed NRK cells in soft agar.Semantic proximity Read ↗

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