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Article

Direct transforming activity of TGF-beta on rat fibroblasts.

International journal of cancer - 29 Mar 1995

Vossbeck H, Strahm B, Höfler P, Bauer G

Abstract excerpt

Treatment of NRK 536 fibroblasts with EGF and transforming growth factor type beta (TGF-beta) is known to lead to the reversible induction of the transformed phenotype in a large percentage of cells. Maintenance of the transformed state is dependent on the continuous presence of the cytokines. Here we show that treatment of these cells with TGF-beta alone leads to the formation of a small percentage of colonies,...

Topics

Agar
Animals
Cells, Cultured
Epidermal Growth Factor
Fibroblasts
Phenotype
Point Mutation
Rats
Stem Cells
Transformation, Genetic
Transforming Growth Factor beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7705938
DOI: 10.1002/ijc.2910610116

Genes

NRK
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7705938-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Direct transforming activity of TGF-beta on rat fibroblasts.PMID 7705938Read ↗

Expression of the TGF alpha integral membrane precursor induces transformation of NRK cells.Semantic proximity Read ↗

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Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects.Semantic proximity Read ↗

Sensitivity of transformed fibroblasts for intercellular induction of apoptosis is determined by their transformed phenotype.Semantic proximity Read ↗

Role of TGF-beta in EGF-induced transformation of NRK cells is sustaining high-level EGF-signaling.Semantic proximity Read ↗

Expression of transfected transforming growth factor alpha induces a motile fibroblast-like phenotype with extracellular matrix-degrading potential in a rat bladder carcinoma cell line.Semantic proximity Read ↗

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