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Article

In vivo tumorigenicity and in vitro sensitivity to tumor-necrosis-factor alpha mediated killing of c-Ha-ras-transformed cells.

Cancer immunology, immunotherapy : CII - 1 Jan 1992

Gonen B, Kahana O, Witz I P

Abstract excerpt

Cellular subclones of high and low tumorigenicity obtained from a mouse c-Ha-ras-transformed clone, were examined for their sensitivity to tumor-necrosis-factor (TNF)-mediated cytotoxicity. Cells of the highly tumorigenic subclones showed a significantly enhanced resistance to the cytotoxic effect of TNF plus cyclohexamide (CHI) as compared to cells of the low-tumorigenic subclones. The enhanced resistance to...

Topics

3T3 Cells
Animals
Cell Line, Transformed
Cell Transformation, Neoplastic
Cycloheximide
Cytotoxicity, Immunologic
Drug Resistance
Gene Expression
Genes, ras
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Receptors, Cell Surface

Receptors, Tumor Necrosis Factor

Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 1327528
DOI: 10.1007/BF01789017
PMCID: PMC11038314

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1327528-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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