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Article

Mutation analysis and loss of heterozygosity of PEDF in central nervous system primitive neuroectodermal tumors.

International journal of cancer - 17 Jul 1997

Slavc I, Rodriguez I R, Mazuruk K, Chader G J, Biegel J A

Abstract excerpt

Deletion of 17p is the most frequent abnormality observed in central nervous system (CNS) primitive neuroectodermal tumors (PNETs), implicating the presence of a tumor suppressor gene which maps to 17p. The gene for pigment epithelium-derived factor (PEDF) has been cloned and mapped to 17p13. PEDF belongs to the serine protease inhibitor (SERPIN) gene family. The PEDF protein has neurotrophic and...

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Identifiers

PMID: 9219833
DOI: 10.1002/(sici)1097-0215(19970717)72:2<277::aid-ijc13>3.0.co;2-d

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