Article
Mutation analysis and loss of heterozygosity of PEDF in central nervous system primitive neuroectodermal tumors.
International journal of cancer - 17 Jul 1997
Slavc I, Rodriguez I R, Mazuruk K, Chader G J, Biegel J A
Abstract excerpt
Deletion of 17p is the most frequent abnormality observed in central nervous system (CNS) primitive neuroectodermal tumors (PNETs), implicating the presence of a tumor suppressor gene which maps to 17p. The gene for pigment epithelium-derived factor (PEDF) has been cloned and mapped to 17p13. PED...
Topics
- Adolescent
- Alleles
- Brain Neoplasms
- Child
- Child, Preschool
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- DNA Mutational Analysis
- Eye Proteins
- Female
- Genes, Tumor Suppressor
- Heterozygote
- Humans
- Infant
- Male
- Mutation
- Nerve Growth Factors
- Neuroectodermal Tumors, Primitive