Article
Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990
Menon A G, Anderson K M, Riccardi V M, Chung R Y, Whaley J M, Yandell D W, Farmer G E, Freiman R N, Lee J K, Li F P
Abstract excerpt
von Recklinghausen neurofibromatosis (NF1) is a common hereditary disorder characterized by neural crest-derived tumors, particularly benign neurofibromas whose malignant transformation to neurofibrosarcomas can be fatal. The NF1 gene has been mapped to a small region of chromosome 17q, but neith...
Topics
- Base Sequence
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- DNA, Neoplasm
- Genetic Carrier Screening
- Genetic Markers
- Humans
- Molecular Sequence Data
- Mutation
- Neoplasm Proteins
- Neurofibroma
- Neurofibromatosis 1