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Article

Molecular and cytogenetic analysis of tumors in von Recklinghausen neurofibromatosis.

Genes, chromosomes & cancer - 1 Jan 1991

Glover T W, Stein C K, Legius E, Andersen L B, Brereton A, Johnson S

Abstract excerpt

Von Recklinghausen neurofibromatosis (NF1) is a common autosomal dominant disorder mapped to 17q11.2 and typically characterized by the occurrence of neural crest-derived tumors. The gene has recently been cloned using reverse genetics or "positional cloning" approaches. Its function, however, remains unknown. We have performed cytogenetic and molecular analyses on 9 malignant tumors from NF1 patients to look for...

Topics

Alleles
Chromosome Aberrations
Chromosomes, Human, Pair 17
DNA, Neoplasm
Genes, Tumor Suppressor
Genetic Markers
Genetic Predisposition to Disease
Humans
Neoplasms
Neurofibromatosis 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1906341
DOI: 10.1002/gcc.2870030111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1906341-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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