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Article

Alterations at chromosome 17 loci in peripheral nerve sheath tumors.

Journal of neuropathology and experimental neurology - 1 Jan 1995

Lothe R A, Slettan A, Saeter G, Brøgger A, Børresen A L, Nesland J M

Abstract excerpt

Little is known about the molecular genetic changes in malignant peripheral nerve sheath tumors (MPNST). Inactivation of the TP53 gene in 17p has been reported in a few tumors. The MPNST is one of the manifestations of neurofibromatosis 1 (NF1), suggesting that the NF1 gene in 17q might be important. We present a study of 15 neurofibromas and MPNST from nine individuals. Seven patients had NF1, and six of these...

Topics

Adolescent
Adult
Alleles
Chromosome Aberrations
Chromosomes, Human, Pair 17
Female
Gene Rearrangement
Humans
Immunologic Techniques
In Situ Hybridization, Fluorescence
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Peripheral Nervous System Neoplasms

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 7815081
DOI: 10.1097/00005072-199501000-00008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7815081-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Alterations at chromosome 17 loci in peripheral nerve sheath tumors.PMID 7815081Read ↗

Frequent genomic imbalances in chromosomes 17, 19, and 22q in peripheral nerve sheath tumours detected by comparative genomic hybridization analysisSemantic proximity Read ↗

Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis.Semantic proximity Read ↗

Genetic alterations in a malignant schwannoma from a patient with neurofibromatosis (NF1).Semantic proximity Read ↗

Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs).Semantic proximity Read ↗

Biallelic inactivation ofTP53 rarely contributes to the development of malignant peripheral nerve sheath tumorsSemantic proximity Read ↗

Biallelic inactivation of TP53 rarely contributes to the development of malignant peripheral nerve sheath tumors.Semantic proximity Read ↗

TP53 mutations are frequent in malignant NF1 tumors.Semantic proximity Read ↗

Loss of heterozygosity on 6q, 16q, and 17p in human central nervous system primitive neuroectodermal tumors.Semantic proximity Read ↗

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Differential<i>NF1</i>,<i>p16</i>, and<i>EGFR</i>Patterns by Interphase Cytogenetics (FISH) in Malignant Peripheral Nerve Sheath Tumor (MPNST) and Morphologically Similar Spindle Cell NeoplasmsSemantic proximity Read ↗

Involvement of multiple chromosome 17p loci in medulloblastoma tumorigenesis.Semantic proximity Read ↗

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