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Article

Loss of NF1 alleles in phaeochromocytomas from patients with type I neurofibromatosis.

Genes, chromosomes & cancer - 1 Jun 1992

Xu W, Mulligan L M, Ponder M A, Liu L, Smith B A, Mathew C G, Ponder B A

Abstract excerpt

Type I neurofibromatosis (NF1) is a common autosomal dominant disorder that affects tissues derived from the neural crest. The manifestations are varied, comprising generalised disorders of growth and development as well as an increased risk of benign and malignant tumours including phaeochromocytomas and neurofibrosarcomas. The NF1 locus has been mapped to chromosome bands 17q11-12, and recently the NF1 gene has...

Topics

Adrenal Gland Neoplasms
Alleles
Blotting, Southern
Chromosomes, Human, Pair 17
DNA Probes
Female
Genes, Neurofibromatosis 1
Humans
Neurofibromatosis 1
Pedigree
Pheochromocytoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1377942
DOI: 10.1002/gcc.2870040411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1377942-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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