Article
Chromosome 17 abnormalities and lack of TP53 mutations in paediatric central nervous system tumours.
Human genetics - 1 Dec 1995
Phelan C M, Liu L, Ruttledge M H, Müntzning K, Ridderheim P A, Collins V P
Abstract excerpt
Central nervous system (CNS) tumours are the most common solid tumours in children. Cytogenetic and molecular genetic studies of these neoplasms have previously shown abnormalities of chromosome 17, implicating genes on this autosome in tumorigenesis. To identify mutations in the TP53 tumour supp...
Topics
- Adolescent
- Adult
- Base Sequence
- Brain Neoplasms
- Child
- Child, Preschool
- Chromosome Aberrations
- Chromosome Deletion
- Chromosome Disorders
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- Conserved Sequence
- DNA Primers
- Female
- Genes, p53
- Humans
- Infant
- Infant, Newborn