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Article

Chromosome 17 abnormalities and lack of TP53 mutations in paediatric central nervous system tumours.

Human genetics - 1 Dec 1995

Phelan C M, Liu L, Ruttledge M H, Müntzning K, Ridderheim P A, Collins V P

Abstract excerpt

Central nervous system (CNS) tumours are the most common solid tumours in children. Cytogenetic and molecular genetic studies of these neoplasms have previously shown abnormalities of chromosome 17, implicating genes on this autosome in tumorigenesis. To identify mutations in the TP53 tumour suppressor gene (17p13.1), we have sequenced the five highly conserved regions of this gene in 29 mixed paediatric CNS...

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Source

Identifiers

PMID: 8522328
DOI: 10.1007/BF00210300

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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