Article
Involvement of multiple chromosome 17p loci in medulloblastoma tumorigenesis.
American journal of human genetics - 1 Mar 1992
Cogen P H, Daneshvar L, Metzger A K, Duyk G, Edwards M S, Sheffield V C
Abstract excerpt
Loss of heterozygosity for sequences located on chromosome 17p in several tumor types is often associated with mutations in the tumor suppressor gene p53. We previously showed consistent deletion of chromosome 17p12-13.1 in medulloblastoma, a common childhood brain tumor. Using denaturing gradient gel electrophoresis and direct sequencing, we have detected p53 mutations in only two of 20 medulloblastoma...
Topics
- Base Sequence
- Cerebellar Neoplasms
- Child
- Child, Preschool
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- Electrophoresis, Gel, Pulsed-Field
- Genes, Tumor Suppressor
- Genes, p53
- Heterozygote