Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression.

doi:10.1002/eji.1830270616

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Article

Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression.

European journal of immunology - 1 Jun 1997

Küppers R, Rajewsky K, Hansmann M L

Abstract excerpt

In the Revised European American Lymphoma (REAL) classification, several subtypes of high-grade lymphomas were combined in the entity diffuse large cell lymphoma (DLL). In the present study, a total of 19 cases of DLL (10 cases of centroblastic lymphoma, 5 cases of mediastinal B cell lymphoma, 2...

Topics

Adult
Aged
Aged, 80 and over
Antibody Formation
B-Lymphocytes
Base Sequence
Cell Differentiation
DNA Mutational Analysis
Female
Gene Rearrangement, B-Lymphocyte
Genes, Immunoglobulin
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Heavy Chains

Immunoglobulin Variable Region

Immunoglobulin kappa-Chains

Lymphoma, Large B-Cell, Diffuse

Male

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 9209491
DOI: 10.1002/eji.1830270616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9209491-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression.PMID 9209491Read ↗

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