Molecular characterization of immunoglobulin gene rearrangements in diffuse large B-cell lymphoma: antigen-driven origin and IGHV4-34 as a particular subgroup of the non-GCB subtype.

doi:10.1016/j.ajpath.2012.07.028

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Article

Molecular characterization of immunoglobulin gene rearrangements in diffuse large B-cell lymphoma: antigen-driven origin and IGHV4-34 as a particular subgroup of the non-GCB subtype.

The American journal of pathology - 1 Nov 2012

Sebastián Elena, Alcoceba Miguel, Balanzategui Ana, Marín Luis, Montes-Moreno Santiago, Flores Teresa, González David, Sarasquete M Eugenia, Chillón M Carmen, Puig Noemí, Corral Rocío, Pardal Emilia, Martín Alejandro, González-Barca Eva, Caballero M Dolores, San Miguel Jesús F, García-Sanz Ramón, González Marcos

Abstract excerpt

The pathogenesis of diffuse large B-cell lymphoma (DLBCL) remains partially unknown. The analysis of the B-cell receptor of the malignant cells could contribute to a better understanding of the DLBCL biology. We studied the molecular features of the immunoglobulin heavy chain (IGH) rearrangements in 165 patients diagnosed with DLBCL not otherwise specified. Clonal IGH rearrangements were amplified according to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 22982190
DOI: 10.1016/j.ajpath.2012.07.028

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