Article
Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas.
Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 2000
Lossos I S, Alizadeh A A, Eisen M B, Chan W C, Brown P O, Botstein D, Staudt L M, Levy R
Abstract excerpt
B cell diffuse large cell lymphoma (B-DLCL) is a heterogeneous group of tumors, based on significant variations in morphology, clinical presentation, and response to treatment. Gene expression profiling has revealed two distinct tumor subtypes of B-DLCL: germinal center B cell-like DLCL and activated B cell-like DLCL. In a separate study, we determined that B-DLCL can also be subdivided into two groups based on...
Topics
- Biopsy
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Lymphoma, B-Cell
- Lymphoma, Large B-Cell, Diffuse
- Molecular Sequence Data
- Mutation
- Oligonucleotide Array Sequence Analysis