Primary mediastinal B-cell lymphoma: high frequency of BCL-6 mutations and consistent expression of the transcription factors OCT-2, BOB.1, and PU.1 in the absence of immunoglobulins.

doi:10.1016/s0002-9440(10)63815-1

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Article

Primary mediastinal B-cell lymphoma: high frequency of BCL-6 mutations and consistent expression of the transcription factors OCT-2, BOB.1, and PU.1 in the absence of immunoglobulins.

The American journal of pathology - 1 Jan 2003

Pileri Stefano A, Gaidano Gianluca, Zinzani Pier Luigi, Falini Brunangelo, Gaulard Philippe, Zucca Emanuele, Pieri Federica, Berra Eva, Sabattini Elena, Ascani Stefano, Piccioli Milena, Johnson Peter W M, Giardini Roberto, Pescarmona Edoardo, Novero Domenico, Piccaluga Pier Paolo, Marafioti Teresa, Alonso Miguel A, Cavalli Franco

Abstract excerpt

Although primary mediastinal (thymic) large B-cell lymphoma has been primarily studied, its precise phenotype, molecular characteristics, and histogenesis are still a matter of debate. The International Extranodal Lymphoma Study Group collected 137 such cases for extensive pathological review. Histologically, the lymphomatous growth was predominantly diffuse with fibrosis that induced compartmentalized cell...

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PMID: 12507907
DOI: 10.1016/s0002-9440(10)63815-1
PMCID: PMC1851125

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MAL
PAX5

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