Article
Analysis of immunoglobulin VH genes in CD10-positive diffuse large B-cell lymphoma.
Pathology international - 1 Sept 2002
Hojo Hiroshi, Kuze Tetuo, Nakamura Naoya, Hashimoto Yuko, Sasaki Yoshikazu, Sato Michiko, Shirakawa Asumi, Abe Masafumi
Abstract excerpt
CD10, a proteolytic enzyme seen in germinal center cells and in the majority of follicular lymphomas, is occasionally expressed in diffuse large B-cell lymphomas (DLBCL). To clarify the origin and cellular characteristics of CD10-positive DLBCL, we analyzed 36 de novo cases of DLBCL for somatic mutations of the immunoglobulin heavy chain variable region (VH) genes and for their immunophenotypes. Expression...
Topics
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Female
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Immunohistochemistry
- Immunophenotyping
- Lymphoma, B-Cell
- Lymphoma, Large B-Cell, Diffuse
- Male