Article
Somatic hypermutations in the VH segment of immunoglobulin genes of CD5-positive diffuse large B-cell lymphomas.
Japanese journal of cancer research : Gann - 1 Nov 1997
Kume M, Suzuki R, Yatabe Y, Kagami Y, Miura I, Miura A B, Morishima Y, Nakamura S, Seto M
Abstract excerpt
De novo CD5-positive (CD5+) diffuse large B-cell lymphoma (DLBL) has recently been identified as constituting a homogeneous subgroup with distinct clinicopathologic and genotypic characteristics, but its origin remains to be elucidated. Previous studies by sequence analysis of the variable region...
Topics
- Adult
- Aged
- Amino Acid Sequence
- Base Sequence
- CD5 Antigens
- DNA, Neoplasm
- Female
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Lymphoma, B-Cell
- Lymphoma, Large B-Cell, Diffuse
- Male
- Middle Aged