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Article

Somatic hypermutations in the VH segment of immunoglobulin genes of CD5-positive diffuse large B-cell lymphomas.

Japanese journal of cancer research : Gann - 1 Nov 1997

Kume M, Suzuki R, Yatabe Y, Kagami Y, Miura I, Miura A B, Morishima Y, Nakamura S, Seto M

Abstract excerpt

De novo CD5-positive (CD5+) diffuse large B-cell lymphoma (DLBL) has recently been identified as constituting a homogeneous subgroup with distinct clinicopathologic and genotypic characteristics, but its origin remains to be elucidated. Previous studies by sequence analysis of the variable region of the immunoglobulin heavy chain (VH) have shown that CD5+ B-cell malignancies such as mantle cell lymphoma (MCL) and...

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Identifiers

PMID: 9439684
DOI: 10.1111/j.1349-7006.1997.tb00333.x
PMCID: PMC5921312

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