Article
Immunoglobulin gene analysis reveals 2 distinct cells of origin for EBV-positive and EBV-negative Burkitt lymphomas.
Blood - 1 Aug 2005
Bellan Cristiana, Lazzi Stefano, Hummel Michael, Palummo Nazzareno, de Santi Margherita, Amato Teresa, Nyagol Joshua, Sabattini Elena, Lazure Thierry, Pileri Stefano A, Raphael Martine, Stein Harald, Tosi Piero, Leoncini Lorenzo
Abstract excerpt
The normal counterpart of the neoplastic B cells in Burkitt lymphoma (BL) is still unclear. Based on immunoglobulin gene rearrangement studies, some authors suggest an origin from germinal center cells and others from memory B cells. However, most of these studies rely on cell lines or on a small series of cases. To help clarify the cell of origin of BL, semi-nested polymerase chain reaction (PCR) was performed...
Topics
- Adolescent
- Adult
- Aged
- B-Lymphocytes
- Burkitt Lymphoma
- Child
- Child, Preschool
- Gene Rearrangement
- Genes, Immunoglobulin
- Germinal Center
- Herpesvirus 4, Human
- Humans
- Immunoglobulin Heavy Chains