Article
Genetic alterations in the Catnb gene but not the H-ras gene in hepatocellular neoplasms and hepatoblastomas of B6C3F(1) mice following exposure to diethanolamine for 2 years.
Chemico-biological interactions - 15 Dec 2003
Hayashi Shim-mo, Ton Thai Vu, Hong Hue-Hua L, Irwin Richard D, Haseman Joseph K, Devereux Theodora R, Sills Robert C
Abstract excerpt
The present study characterized the immunohistochemical localization of beta-catenin protein in hepatocellular neoplasms and hepatoblastomas in B6C3F(1) mice exposed to diethanolamine (DEA) for 2 years and evaluated genetic alterations in the Catnb and H-ras genes which are known to play important roles in the pathogenesis of liver malignancies. Genomic DNA was isolated from paraffin sections of each liver tumor....
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