Ras-transduced diethylnitrosamine-treated hepatocytes develop into cancers of mixed phenotype in vivo.

Article

Ras-transduced diethylnitrosamine-treated hepatocytes develop into cancers of mixed phenotype in vivo.

Cancer research - 15 Nov 1995

Lin Y Z, Brunt E M, Bowling W, Hafenrichter D G, Kennedy S C, Flye M W, Ponder K P

Abstract excerpt

The cell of origin of hepatocellular carcinoma (HCC) is controversial. A method for marking cells of different lineages in vivo and then determining their carcinogenic potential should resolve this issue. A retroviral vector expressing activated ras and beta-gal genes (Ras-gal) was transferred in...

Topics

Animals
Cocarcinogenesis
Diethylnitrosamine
Gene Transfer Techniques
Genes, ras
Hematopoiesis
Liver Neoplasms, Experimental
Male
Mutation
Phenotype
Rats
Rats, Inbred F344

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