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Article

Dichloroacetate and trichloroacetate promote clonal expansion of anchorage-independent hepatocytes in vivo and in vitro.

Toxicology and applied pharmacology - 1 Jun 1998

Stauber A J, Bull R J, Thrall B D

Abstract excerpt

Dichloroacetate (DCA) and trichloroacetate (TCA) are hepatocarcinogenic by-products of water chlorination and metabolites of several industrial solvents. To determine whether DCA and TCA promote the clonal expansion of anchorage-independent liver cells in vitro, a modification of the soft agar assay (over agar assay) was utilized to quantitate growth and analyze phenotype of anchorage-independent hepatocellular...

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Identifiers

PMID: 9653059
DOI: 10.1006/taap.1998.8417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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