Article
Dichloroacetate and trichloroacetate promote clonal expansion of anchorage-independent hepatocytes in vivo and in vitro.
Toxicology and applied pharmacology - 1 Jun 1998
Stauber A J, Bull R J, Thrall B D
Abstract excerpt
Dichloroacetate (DCA) and trichloroacetate (TCA) are hepatocarcinogenic by-products of water chlorination and metabolites of several industrial solvents. To determine whether DCA and TCA promote the clonal expansion of anchorage-independent liver cells in vitro, a modification of the soft agar as...
Topics
- Administration, Oral
- Animals
- Cell Count
- Cell Separation
- Cells, Cultured
- Dichloroacetic Acid
- Dose-Response Relationship, Drug
- Genes, fos
- Genes, jun
- Liver
- Liver Neoplasms, Experimental
- Male
- Mice
- Neoplastic Stem Cells
- Phenotype
- Trichloroacetic Acid