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Article

Oval cell lines OC/CDE 6 and OC/CDE 22 give rise to cholangio-cellular and undifferentiated carcinomas after transformation.

Laboratory investigation; a journal of technical methods and pathology - 1 Nov 1994

Steinberg P, Steinbrecher R, Radaeva S, Schirmacher P, Dienes H P, Oesch F, Bannasch P

Abstract excerpt

BACKGROUND: There is compelling evidence for a parenchymal origin of the predominant cell lineage leading from preneoplastic clear and acidophilic glycogen storage foci through mixed and basophilic cell populations to hepatocellular carcinomas in the rat. However, a controversial question remains to be answered: Do the basophilic cell foci invariably originate from parenchymal cells or do oval cells also have the...

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PMID: 7526039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Oval cell lines OC/CDE 6 and OC/CDE 22 give rise to cholangio-cellular and undifferentiated carcinomas after transformation.PMID 7526039Read ↗

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Differentiation status of rat ductal cells and ethionine-induced hepatic carcinomas defined with surface-reactive monoclonal antibodies.Semantic proximity Read ↗

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Delineation of antigenic pathways of ethionine-induced liver cancer in the rat.Semantic proximity Read ↗

Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartmentSemantic proximity Read ↗

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Mallory body forming cells express the preneoplastic hepatocyte phenotype.Semantic proximity Read ↗

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