Oval cell lines OC/CDE 6 and OC/CDE 22 give rise to cholangio-cellular and undifferentiated carcinomas after transformation.

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Article

Oval cell lines OC/CDE 6 and OC/CDE 22 give rise to cholangio-cellular and undifferentiated carcinomas after transformation.

Laboratory investigation; a journal of technical methods and pathology - 1 Nov 1994

Steinberg P, Steinbrecher R, Radaeva S, Schirmacher P, Dienes H P, Oesch F, Bannasch P

Abstract excerpt

BACKGROUND: There is compelling evidence for a parenchymal origin of the predominant cell lineage leading from preneoplastic clear and acidophilic glycogen storage foci through mixed and basophilic cell populations to hepatocellular carcinomas in the rat. However, a controversial question remains...

Topics

Animals
Cell Differentiation
Cell Line
Epithelium
Keratins
Liver
Liver Neoplasms, Experimental
Neoplastic Stem Cells
Phenotype
Rats
Rats, Sprague-Dawley

Source

Open in PubMed

Identifiers

PMID: 7526039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7526039-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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