Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene.

Toxicology and applied pharmacology - 1 Jul 2002

Bull Richard J, Orner Gayle A, Cheng Rita S, Stillwell Lisa, Stauber Anja J, Sasser Lyle B, Lingohr Melissa K, Thrall Brian D

Abstract excerpt

Determining the key events in the induction of liver cancer in mice by trichloroethylene (TRI) is important in the determination of how risks from this chemical should be treated at low doses. At least two metabolites can contribute to liver cancer in mice, dichloroacetate (DCA) and trichloroacetate (TCA). TCA is produced from metabolism of TRI at systemic concentrations that can clearly contribute to this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Interactions

Share to Genes, jun

Share to Genes, ras

Share to Liver Neoplasms

Share to Random Allocation

Share to Solvents

Source

Identifiers

PMID: 12127263
DOI: 10.1006/taap.2002.9427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene.PMID 12127263Read ↗

ras proto-oncogene activation in dichloroacetic acid-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice.Semantic proximity Read ↗

Differences in phenotype and cell replicative behavior of hepatic tumors induced by dichloroacetate (DCA) and trichloroacetate (TCA).Semantic proximity Read ↗

Evidence for the lack of base-change and small-deletion mutation induction by trichloroethylene in lacZ transgenic mice.Semantic proximity Read ↗

Dichloroacetate and trichloroacetate promote clonal expansion of anchorage-independent hepatocytes in vivo and in vitro.Semantic proximity Read ↗

Activation and attenuation of apoptosis of CD4+ T cells following in vivo exposure to two common environmental toxicants, trichloroacetaldehyde hydrate and trichloroacetic acid.Semantic proximity Read ↗

Evaluating human variability in chemical risk assessment: hazard identification and dose-response assessment for noncancer oral toxicity of trichloroethylene.Semantic proximity Read ↗

Dichloroacetic acid and related compounds: induction of prophage in E. coli and mutagenicity and mutation spectra in Salmonella TA100.Semantic proximity Read ↗

Trichloroethylene exposure and specific somatic mutations in patients with renal cell carcinoma.Semantic proximity Read ↗

Hepatocarcinogenicity of chlordane in B6C3F1 and B6D2F1 male mice: evidence for regression in B6C3F1 mice and carcinogenesis independent of ras proto-oncogene activation.Semantic proximity Read ↗

Human variability and susceptibility to trichloroethylene.Semantic proximity Read ↗

Role of H-ras gene in chronic liver damage in mice. By using transgenic mice carrying a human C-H-ras proto-oncogene without mutations.Semantic proximity Read ↗

Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.