Article
Hepatocarcinogenicity of chlordane in B6C3F1 and B6D2F1 male mice: evidence for regression in B6C3F1 mice and carcinogenesis independent of ras proto-oncogene activation.
Carcinogenesis - 1 Nov 1995
Malarkey D E, Devereux T R, Dinse G E, Mann P C, Maronpot R R
Abstract excerpt
Logistic regression analysis of age-specific prevalences for neoplastic and non-neoplastic liver lesions was used to examine treatment responses for B6C3F1 and B6D2F1 male mice continuously exposed to chlordane (55 p.p.m.) and to determine whether neoplasms were dependent on continuous exposure i...
Topics
- Animals
- Chlordan
- Gene Expression Regulation
- Genes, ras
- Hypertrophy
- Insecticides
- Liver
- Liver Neoplasms, Experimental
- Male
- Mice
- Mice, Inbred Strains
- Mutation