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Article

ras proto-oncogene activation in dichloroacetic acid-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice.

Carcinogenesis - 1 Oct 1994

Anna C H, Maronpot R R, Pereira M A, Foley J F, Malarkey D E, Anderson M W

Abstract excerpt

The frequency and mutation spectra of proto-oncogene activation in hepatocellular neoplasms induced by tetrachloroethylene, trichloroethylene and dichloroacetic acid were examined to help define the molecular basis for their carcinogenicity. H-ras codon 61 activation was not significantly different among dichloroacetic acid- and trichloroethylene-induced and combined historical and concurrent control...

Topics

Animals
Base Sequence
Carcinogenicity Tests
Cell Transformation, Neoplastic
Codon
Dichloroacetic Acid
Exons
Gene Expression Regulation, Neoplastic
Genes, ras
Liver Neoplasms, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred Strains

Mice, Nude

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Tetrachloroethylene

Source

Identifiers

PMID: 7955063
DOI: 10.1093/carcin/15.10.2255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7955063-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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