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Article

Inactivation of the transforming growth factor β type II receptor in human small cell lung cancer cell lines

12 Feb 1999

Abstract excerpt

Transforming growth factor beta (TGF-beta) exerts a growth inhibitory effect on many cell types through binding to two types of receptors, the type I and II receptors. Resistance to TGF-beta due to lack of type II receptor (RII) has been described in some cancer types including small cell lung cancer (SCLC). The purpose of this study was to examine the cause of absent RII expression in SCLC cell lines. Northern...

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PMID: 10098728
DOI: 10.1038/sj.bjc.6690161

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Source receipt: pubmed, retrieved 7 Sept 2026.

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