Article
Absence of mutations in the analysis of coding sequences of the entire transforming growth factor-beta type II receptor gene in sporadic human breast cancers.
Oncology reports - 1 Jan 2000
Takenoshita S, Mogi A, Tani M, Osawa H, Sunaga H, Kakegawa H, Yanagita Y, Koida T, Kimura M, Fujita K I, Kato H, Kato R, Nagamachi Y
Abstract excerpt
The transforming growth factor-beta (TGFbeta) binds the type II TGFbeta growth factor receptor (TGFbetaRII) to inhibit the growth of most epithelial tissues. Most human colon and gastric cancers with microsatellite instability (MI) have frameshift mutations in polynucleotide repeats within the TGFbetaRII coding region; these mutations truncate the receptor protein and disable the serine/threonine kinase to...
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