Article
DPC4 gene mutation in colitis associated neoplasia.
Gut - 1 Jan 1997
Hoque A T, Hahn S A, Schutte M, Kern S E
Abstract excerpt
BACKGROUND: Colitis associated dysplasia and cancer often have deletions involving the long arm of chromosome 18q, suggesting the location of a tumour suppressor gene critical for their tumorigenesis. The DPC4 gene, which is genetically inactivated in pancreatic and other cancers, has recently be...
Topics
- Adult
- Aged
- Base Sequence
- Chromosome Deletion
- Chromosomes, Human, Pair 18
- Colitis, Ulcerative
- Colorectal Neoplasms
- Crohn Disease
- Exons
- Genes, Tumor Suppressor
- Heterozygote
- Humans
- Middle Aged
- Molecular Sequence Data
- Mutation
- Oncogenes
- Polymerase Chain Reaction