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Article

Somatic alterations of the DPC4 gene in human colorectal cancers in vivo.

Gastroenterology - 1 Nov 1996

Takagi Y, Kohmura H, Futamura M, Kida H, Tanemura H, Shimokawa K, Saji S

Abstract excerpt

BACKGROUND & AIMS: The chromosome region 18q21 has been shown to be frequently deleted in colorectal cancers, and such frequent allelic loss is a hallmark of the presence of a tumor-suppressor gene. The DPC4 gene, which is located at 18q21, has been identified as a tumor-suppressor gene from examination of pancreatic cancers. The aim of the present study was to determine if it might also be altered in colorectal...

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Identifiers

PMID: 8898652
DOI: 10.1053/gast.1996.v111.pm8898652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Somatic alterations of the DPC4 gene in human colorectal cancers in vivo.PMID 8898652Read ↗

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Frequent loss of SMAD4/DPC4 protein in colorectal cancersSemantic proximity Read ↗

Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms.Semantic proximity Read ↗

Higher frequency of DPC4/Smad4 alterations in pancreatic cancer cell lines than in primary pancreatic adenocarcinomas.Semantic proximity Read ↗

Mutations of the DPC4/Smad4 gene in neuroendocrine pancreatic tumors.Semantic proximity Read ↗

Identification of a chromosome 18q gene that is altered in colorectal cancers.Semantic proximity Read ↗

Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients.Semantic proximity Read ↗

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