Article
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.
Science (New York, N.Y.) - 19 Jan 1996
Hahn S A, Schutte M, Hoque A T, Moskaluk C A, da Costa L T, Rozenblum E, Weinstein C L, Fischer A, Yeo C J, Hruban R H, Kern S E
Abstract excerpt
About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were analyzed for convergent sites of homozygous deletion. Twenty-five of 84 tumors had homozygous deletions at 18q21.1, a site that excludes DCC (a candidate suppressor gene for colorectal cancer) and includes DPC4, a gene similar in sequence...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Division
- Chromosome Mapping
- Chromosomes, Human, Pair 18
- DNA-Binding Proteins
- Gene Deletion
- Gene Expression
- Genes, Tumor Suppressor