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Article

The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression.

Biochimica et biophysica acta - 18 Oct 2000

Barberá V M, Martín M, Mariñoso L, Munné A, Carrato A, Real F X, Fabre M

Abstract excerpt

UNLABELLED: The 18q21 region is frequently altered in gastrointestinal tumors. Three candidate tumor suppressor genes have been identified in it: DCC, Smad4/DPC4 and Smad2; the mechanisms involving their inactivation have not been completely elucidated. In this study, genetic losses at 18q21 and expression of DCC and DPC4 in colorectal (n=12) and pancreatic (n=16) cell lines and in colorectal tissues (n=10) were...

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Source

Identifiers

PMID: 11040453
DOI: 10.1016/s0925-4439(00)00054-5

Genes

DCC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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