Allelic loss and mutational analysis of the DPC4 gene in esophageal adenocarcinoma.

Article

Allelic loss and mutational analysis of the DPC4 gene in esophageal adenocarcinoma.

Cancer research - 1 Oct 1996

Barrett M T, Schutte M, Kern S E, Reid B J

Abstract excerpt

DPC4, a recently cloned gene located on 18q2l.l, is inactivated in almost one half of pancreatic adenocarcinomas. To determine whether DPC4 inactivation is involved in esophageal adenocarcinoma, we have analyzed aneuploid populations from biopsies of 35 patients with Barrett's esophagus who had p...

Topics

Alleles
Aneuploidy
Barrett Esophagus
Chromosomes, Human, Pair 18
DNA Mutational Analysis
DNA-Binding Proteins
Disease Progression
Esophageal Neoplasms
Humans
Precancerous Conditions
Sequence Deletion
Smad4 Protein
Trans-Activators

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