Article
Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas.
Oncogene - 28 Aug 1997
MacGrogan D, Pegram M, Slamon D, Bookstein R
Abstract excerpt
Allelic deletions of chromosome 18q are reported to be common in prostate and colorectal cancers, suggesting that one or more tumor suppressor genes on 18q are involved in the genesis of these neoplasms. The DPC4 gene, a recently identified candidate tumor suppressor in 18q21, was examined for ev...
Topics
- Alleles
- Chromosomes, Human, Pair 18
- Colorectal Neoplasms
- DNA Mutational Analysis
- DNA-Binding Proteins
- Gene Deletion
- Genes, Tumor Suppressor
- Homozygote
- Humans
- Male
- Point Mutation
- Prostatic Neoplasms