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Article

Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas.

Oncogene - 28 Aug 1997

MacGrogan D, Pegram M, Slamon D, Bookstein R

Abstract excerpt

Allelic deletions of chromosome 18q are reported to be common in prostate and colorectal cancers, suggesting that one or more tumor suppressor genes on 18q are involved in the genesis of these neoplasms. The DPC4 gene, a recently identified candidate tumor suppressor in 18q21, was examined for evidence of inactivation in prostatic carcinomas, and results compared to those of a parallel analysis of colorectal...

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Identifiers

PMID: 9285566
DOI: 10.1038/sj.onc.1201232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas.PMID 9285566Read ↗

Somatic alterations of the DPC4 gene in human colorectal cancers in vivo.Semantic proximity Read ↗

The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression.Semantic proximity Read ↗

Higher frequency of DPC4/Smad4 alterations in pancreatic cancer cell lines than in primary pancreatic adenocarcinomas.Semantic proximity Read ↗

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.Semantic proximity Read ↗

Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients.Semantic proximity Read ↗

Frequent loss of SMAD4/DPC4 protein in colorectal cancersSemantic proximity Read ↗

Somatic allelic loss at the DCC, APC, nm23-H1 and p53 tumor suppressor gene loci in human prostatic carcinoma.Semantic proximity Read ↗

Status of the DPC4 tumor suppressor gene in sporadic colon adenocarcinoma of Croatian patients: identification of a novel somatic mutation.Semantic proximity Read ↗

Role of Smad4 (DPC4) inactivation in human cancer.Semantic proximity Read ↗

Allelic imbalance in chromosome band 18q21 and SMAD4 mutations in ovarian cancers.Semantic proximity Read ↗

Two somatic biallelic lesions within and near SMAD4 in a human breast cancer cell line.Semantic proximity Read ↗

Mutations of the DPC4/Smad4 gene in neuroendocrine pancreatic tumors.Semantic proximity Read ↗

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