Article
Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms.
Oncogene - 5 Dec 1996
Lei J, Zou T T, Shi Y Q, Zhou X, Smolinski K N, Yin J, Souza R F, Appel R, Wang S, Cymes K, Chan O, Abraham J M, Harpaz N, Meltzer S J
Abstract excerpt
Homozygously Deleted in Pancreatic Cancer 4 (DPC4), a recently identified candidate tumor suppressor gene, was previously shown to be altered in human pancreatic cancers. We examined DPC4 mutation in 30 examples of three other types of gastrointestinal malignancy: 10 esophageal cancers, 10 gastri...
Topics
- Colitis, Ulcerative
- Colonic Neoplasms
- DNA Mutational Analysis
- DNA-Binding Proteins
- Esophageal Neoplasms
- Genes, Tumor Suppressor
- Humans
- Mutation
- Polymerase Chain Reaction
- Precancerous Conditions
- Smad4 Protein
- Stomach Neoplasms
- Trans-Activators