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Article

Status of the DPC4 tumor suppressor gene in sporadic colon adenocarcinoma of Croatian patients: identification of a novel somatic mutation.

Mutation research - 14 Apr 2004

Popović Hadzija Marijana, Radosevic Senka, Kovacević Duje, Lukac Josip, Hadzija Mirko, Spaventi Radan, Pavelić Kresimir, Kapitanović Sanja

Abstract excerpt

Loss of heterozygosity (LOH) of loci on chromosome 18q occurs in a majority of colorectal cancers. The DPC4 (Smad4) tumor suppressor gene, located at 18q21.1, may be a predisposing gene for Juvenile Polyposis Syndrome. To investigate alterations of the DPC4 gene in sporadic colon adenocarcinoma, a panel of 60 tumor specimens from Croatian patients was surveyed for evidence of LOH and also for mutations within the...

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Source

Identifiers

PMID: 15063137
DOI: 10.1016/j.mrfmmm.2003.12.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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