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Article

Loss of chromosome 18q and DPC4 (Smad4) mutations in appendiceal adenocarcinomas.

Oncogene - 22 Jan 2004

Maru Dipen, Wu Tsung-Teh, Canada Amanda, Houlihan Patrick S, Hamilton Stanley R, Rashid Asif

Abstract excerpt

Appendiceal adenocarcinomas are uncommon, and the genetic alterations present in these tumors are not well characterized. We studied genetic alterations including loss of chromosome 18q (location of DCC, DPC4, and JV-18 genes), and mutations of the DPC4 (SMAD4) and beta-catenin genes in 28 appendiceal adenocarcinomas, consisting of 17 mucinous and 11 nonmucinous carcinomas. Chromosome 18q loss was present in 57%...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14647445
DOI: 10.1038/sj.onc.1207194

Genes

DCC
SMAD4

Provenance

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