Article
Tumor promotion by depleting cells of protein kinase C delta.
Molecular and cellular biology - 1 Jun 1997
Lu Z, Hornia A, Jiang Y W, Zang Q, Ohno S, Foster D A
Abstract excerpt
Tumor-promoting phorbol esters activate, but then deplete cells of, protein kinase C (PKC) with prolonged treatment. It is not known whether phorbol ester-induced tumor promotion is due to activation or depletion of PKC. In rat fibroblasts overexpressing the c-Src proto-oncogene, the phorbol este...
Topics
- Animals
- Antineoplastic Agents
- Bryostatins
- Carcinogens
- Cell Transformation, Neoplastic
- Cells, Cultured
- Down-Regulation
- Fibroblasts
- Isoenzymes
- Lactones
- Macrolides
- Phenotype
- Protein Kinase C
- Protein Kinase C-alpha
- Protein Kinase C-delta
- Protein Kinase C-epsilon
- Proto-Oncogene Proteins pp60(c-src)
- Rats