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Article

Tumor promotion by depleting cells of protein kinase C delta.

Molecular and cellular biology - 1 Jun 1997

Lu Z, Hornia A, Jiang Y W, Zang Q, Ohno S, Foster D A

Abstract excerpt

Tumor-promoting phorbol esters activate, but then deplete cells of, protein kinase C (PKC) with prolonged treatment. It is not known whether phorbol ester-induced tumor promotion is due to activation or depletion of PKC. In rat fibroblasts overexpressing the c-Src proto-oncogene, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induced anchorage-independent growth and other transformation-related...

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Identifiers

PMID: 9154841
DOI: 10.1128/MCB.17.6.3418
PMCID: PMC232195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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