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Article

Protein kinase C delta is required for survival of cells expressing activated p21RAS.

The Journal of biological chemistry - 4 May 2007

Xia Shuhua, Forman Lora W, Faller Douglas V

Abstract excerpt

Inhibition of protein kinase C (PKC) activity in transformed cells and tumor cells containing activated p21(RAS) results in apoptosis. To investigate the pro-apoptotic pathway induced by the p21(RAS) oncoprotein, we first identified the specific PKC isozyme necessary to prevent apoptosis in the presence of activated p21(RAS). Dominant-negative mutants of PKC, short interfering RNA vectors, and PKC...

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Identifiers

PMID: 17350960
DOI: 10.1074/jbc.M610225200
PMCID: PMC3527128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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