Article
Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta.
The Journal of biological chemistry - 8 Mar 1996
Denning M F, Dlugosz A A, Threadgill D W, Magnuson T, Yuspa S H
Abstract excerpt
The expression of an oncogenic rasHa gene in epidermal keratinocytes stimulates the tyrosine phosphorylation of protein kinase C delta and inhibits its enzymatic activity (Denning, M. F., Dlugosz, A. A., Howett, M. K., and Yuspa, S. H. (1993) J. Biol. Chem. 268, 26079-26081). Keratinocytes expres...
Topics
- Alleles
- Aluminum Compounds
- Animals
- Animals, Newborn
- Cell Line
- Cell Transformation, Neoplastic
- Epidermal Growth Factor
- ErbB Receptors
- Fluorides
- GTP-Binding Proteins
- Gene Expression
- Genes, ras
- Isoenzymes
- Keratinocytes
- Mice
- Mice, Inbred BALB C
- Mice, Mutant Strains
- Mutagenesis