Article
Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cells.
Cancer research - 1 Dec 2006
Li Haiyang, Weinstein I Bernard
Abstract excerpt
Although alterations in the expressions of protein kinase C (PKC) have been implicated in breast carcinogenesis, the roles of specific isoforms in this process remain elusive. In the present study, we examined the specific roles of PKCbeta1 and beta2 in growth control in human breast cancer cell lines. The PKCbeta-specific inhibitor LY379196 significantly inhibited growth of the breast cancer cell lines MCF-7,...
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