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Article

Induction of cell death by stimulation of protein kinase C in human epithelial cells expressing a mutant ras oncogene: a potential therapeutic target.

British journal of cancer - 1 Sept 1998

Hall-Jackson C A, Jones T, Eccles N G, Dawson T P, Bond J A, Gescher A, Wynford-Thomas D

Abstract excerpt

Ras oncogene activation is a key genetic event in several types of human cancer, making its signal pathways an ideal target for novel therapies. We previously showed that expression of mutant ras sensitizes human thyroid epithelial cells to induction of cell death by treatment with phorbol 12-myristate 13-acetate (PMA) and other phorbol esters. We have now investigated further the nature and mechanism of this...

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Identifiers

PMID: 9744505
DOI: 10.1038/bjc.1998.554
PMCID: PMC2063067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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