Partial down-regulation of protein kinase C reverses the growth inhibitory effect of phorbol esters on HepG2 cells.

doi:10.1002/jcp.1041450225

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Article

Partial down-regulation of protein kinase C reverses the growth inhibitory effect of phorbol esters on HepG2 cells.

Journal of cellular physiology - 1 Nov 1990

Duronio V, Huber B E, Jacobs S

Abstract excerpt

Phorbol ester treatment of HepG2, a human tumorigenic cell line, caused rapid morphological changes characterized by a flattening and spreading of the cells that coincided with a rapid inhibition of thymidine incorporation. Within 24 h, cell division was completely inhibited, suggesting the cells had entered a quiescent state. Continued incubation in the presence of phorbol esters resulted in the resumption of...

Topics

Carcinoma, Hepatocellular
Cell Differentiation
Cell Division
Down-Regulation
Gene Expression Regulation
Humans
Liver
Liver Neoplasms
Phenotype
Phorbol Esters
Poly A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinase C

Proto-Oncogene Proteins c-myc

RNA, Messenger

Receptor, Insulin

Receptors, Cell Surface

Receptors, Somatomedin

Thymidine

Source

Open in PubMed

Identifiers

PMID: 1978839
DOI: 10.1002/jcp.1041450225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1978839-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Partial down-regulation of protein kinase C reverses the growth inhibitory effect of phorbol esters on HepG2 cells.PMID 1978839Read ↗

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