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Article

Partial down-regulation of protein kinase C reverses the growth inhibitory effect of phorbol esters on HepG2 cells.

Journal of cellular physiology - 1 Nov 1990

Duronio V, Huber B E, Jacobs S

Abstract excerpt

Phorbol ester treatment of HepG2, a human tumorigenic cell line, caused rapid morphological changes characterized by a flattening and spreading of the cells that coincided with a rapid inhibition of thymidine incorporation. Within 24 h, cell division was completely inhibited, suggesting the cells had entered a quiescent state. Continued incubation in the presence of phorbol esters resulted in the resumption of...

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Identifiers

PMID: 1978839
DOI: 10.1002/jcp.1041450225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Partial down-regulation of protein kinase C reverses the growth inhibitory effect of phorbol esters on HepG2 cells.PMID 1978839Read ↗

Tumor promotion by depleting cells of protein kinase C delta.Semantic proximity Read ↗

Downregulation of protein kinase C-gamma is independent of a functional kinase domain.Semantic proximity Read ↗

Effect of phorbol ester and platelet-derived growth factor on protein kinase C in rat hepatic stellate cells.Semantic proximity Read ↗

Induction of cell death by stimulation of protein kinase C in human epithelial cells expressing a mutant ras oncogene: a potential therapeutic target.Semantic proximity Read ↗

A point mutation at the putative ATP-binding site of protein kinase C alpha abolishes the kinase activity and renders it down-regulation-insensitive. A molecular link between autophosphorylation and down-regulation.Semantic proximity Read ↗

Differentiation of vascular smooth muscle cells and the regulation of protein kinase C-alpha.Semantic proximity Read ↗

Cell cycle gene regulation in reversibly differentiated new human hepatoma cell lines.Semantic proximity Read ↗

Phorbol diester-induced alterations in the expression of protein kinase C isozymes and their mRNAs. Analysis in wild-type and phorbol diester-resistant HL-60 cell clones.Semantic proximity Read ↗

Effect of serum starvation on expression and phosphorylation of PKC-? and p53 in V79 cells: Implications for cell deathSemantic proximity Read ↗

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Cytoskeletal reorganization induced by retinoic acid treatment of human endometrial adenocarcinoma (RL95-2) cells is correlated with alterations in protein kinase C-alpha.Semantic proximity Read ↗

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