Protein Kinase C Isozymes, Novel Phorbol Ester Receptors and Cancer Chemotherapy

Abstract excerpt

Recent years have seen extensive growth in the understanding of the role(s) of the various PKC isozymes and novel receptors for the phorbol ester tumor promoters. The PKC family of serine-threonine kinases is an important regulator of signaling cascades that control cell proliferation and death, and therefore represent targets for cancer therapy. While past interests have focused on PKC-selective inhibitors, more...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer Treatment and Pharmacology
• Share to Computational Drug Discovery Methods
• Share to Protein Kinase Regulation and GTPase Signaling