Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein kinase C as a tumor suppressor.

Seminars in cancer biology - 1 Feb 2018

Newton Alexandra C

Abstract excerpt

Protein kinase C (PKC) has historically been considered an oncoprotein. This stems in large part from the discovery in the early 1980s that PKC is directly activated by tumor-promoting phorbol esters. Yet three decades of clinical trials using PKC inhibitors in cancer therapies not only failed, but in some cases worsened patient outcome. Why has targeting PKC in cancer eluded successful therapies? Recent studies...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enzyme Activation
Share to Genes, Tumor Suppressor
Share to Isoenzymes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Share to Phorbol Esters

Share to Protein Kinase C

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 28476658
DOI: 10.1016/j.semcancer.2017.04.017
PMCID: PMC5668200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein kinase C as a tumor suppressor.PMID 28476658Read ↗

Protein Kinase C at the Crossroad of Mutations, Cancer, Targeted Therapy and Immune ResponseSemantic proximity Read ↗

Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor.Semantic proximity Read ↗

Equivocal, explicit and emergent actions of PKC isoforms in cancer.Semantic proximity Read ↗

The PKC universe keeps expanding: From cancer initiation to metastasis.Semantic proximity Read ↗

Protein kinase C: perfectly balanced.Semantic proximity Read ↗

Reversing the Paradigm: Protein Kinase C as a Tumor SuppressorSemantic proximity Read ↗

Cancer-associated mutations in protein kinase C theta are loss-of-function.Semantic proximity Read ↗

The complexities of PKCα signaling in cancer.Semantic proximity Read ↗

The many hats of protein kinase Cδ: one enzyme with many functions.Semantic proximity Read ↗

DNA-PKcs: A Targetable Protumorigenic Protein KinaseSemantic proximity Read ↗

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.Semantic proximity Read ↗

Protein Kinase C Isozymes, Novel Phorbol Ester Receptors and Cancer ChemotherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.