Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Src family kinases phosphorylate protein kinase C delta on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes.

The Journal of biological chemistry - 5 Apr 2002

Joseloff Elizabeth, Cataisson Christophe, Aamodt Heather, Ocheni Henrietta, Blumberg Peter, Kraker Alan J, Yuspa Stuart H

Abstract excerpt

Protein kinase C delta (PKC delta) is tyrosine-phosphorylated and catalytically inactive in mouse keratinocytes transformed by a ras oncogene. In several other model systems, Src kinases are upstream regulators of PKC delta. To examine this relationship in epidermal carcinogenesis, v-ras transformed mouse keratinocytes were treated with a selective Src kinase inhibitor (PD 173958). PD 173958 decreased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Keratinocytes
Share to Lactones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrolides

Share to Oligonucleotides, Antisense

Share to Phenylalanine

Share to Protein Kinase C

Share to Protein Kinase C-delta

Share to src-Family Kinases

Source

Identifiers

PMID: 11812791
DOI: 10.1074/jbc.M111618200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Src family kinases phosphorylate protein kinase C delta on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes.PMID 11812791Read ↗

Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta.Semantic proximity Read ↗

Srcasm corrects Fyn-induced epidermal hyperplasia by kinase down-regulation.Semantic proximity Read ↗

Tumor promotion by depleting cells of protein kinase C delta.Semantic proximity Read ↗

C-terminal Src kinase controls development and maintenance of mouse squamous epithelia.Semantic proximity Read ↗

Alterations in protein kinase C isozymes alpha and beta 2 in activated Ha-ras containing papillomas in the absence of an increase in diacylglycerol.Semantic proximity Read ↗

Protein kinase C δ is a downstream effector of oncogenic K-ras in lung tumors.Semantic proximity Read ↗

Overexpression of a constitutively active form of c-src in skin epidermis increases sensitivity to tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.Semantic proximity Read ↗

Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.Semantic proximity Read ↗

Proteomic Analysis of Src Family Kinase Phosphorylation States in Cancer Cells Suggests Deregulation of the Unique Domain.Semantic proximity Read ↗

Deletion of the regulatory domain of protein kinase C alpha exposes regions in the hinge and catalytic domains that mediate nuclear targeting.Semantic proximity Read ↗

Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells.Semantic proximity Read ↗

Characterization of benzo[a]pyrene-initiated mouse skin papillomas for Ha-ras mutations and protein kinase C levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.