Protein kinase C-delta inactivation inhibits the proliferation and survival of cancer stem cells in culture and in vivo

Abstract excerpt

BACKGROUND: A subpopulation of tumor cells with distinct stem-like properties (cancer stem-like cells, CSCs) may be responsible for tumor initiation, invasive growth, and possibly dissemination to distant organ sites. CSCs exhibit a spectrum of biological, biochemical, and molecular features that are consistent with a stem-like phenotype, including growth as non-adherent spheres (clonogenic potential), ability to...

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