Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.

doi:10.1074/jbc.271.38.23512

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Article

Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.

The Journal of biological chemistry - 20 Sept 1996

Ueda Y, Hirai S i, Osada S i, Suzuki A, Mizuno K, Ohno S

Abstract excerpt

Although the involvement of protein kinase C (PKC) in the activation of the mitogen-activated protein (MAP) kinase pathway has been implicated through experiments using 12-O-tetradecanoylphorbol-13-acetate (TPA), there has been no direct demonstration that PKC activates the MAP kinase pathway. A...

Topics

3T3 Cells
Animals
COS Cells
Calcium-Calmodulin-Dependent Protein Kinases
Enzyme Activation
Epidermal Growth Factor
Isoenzymes
MAP Kinase Kinase 1
Mice
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitogen-Activated Protein Kinases

Models, Biological

Mutation

Protein Kinase C

Protein Kinase C-delta

Protein Serine-Threonine Kinases

Protein-Tyrosine Kinases

Source

Open in PubMed

Identifiers

PMID: 8798560
DOI: 10.1074/jbc.271.38.23512

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8798560-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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