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Article

Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.

The Journal of biological chemistry - 20 Sept 1996

Ueda Y, Hirai S i, Osada S i, Suzuki A, Mizuno K, Ohno S

Abstract excerpt

Although the involvement of protein kinase C (PKC) in the activation of the mitogen-activated protein (MAP) kinase pathway has been implicated through experiments using 12-O-tetradecanoylphorbol-13-acetate (TPA), there has been no direct demonstration that PKC activates the MAP kinase pathway. A Raf-dependent intact cell assay system for monitoring the activation of MAPK/ERK kinase (MEK) and extracellular...

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Identifiers

PMID: 8798560
DOI: 10.1074/jbc.271.38.23512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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