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Article

Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells.

Molecular and cellular biology - 1 Jun 1997

Stang S, Bottorff D, Stone J C

Abstract excerpt

v-H-ras effector mutants have been assessed for transforming activity and for the ability of the encoded proteins to interact with Raf-1-, B-Raf-, byr2-, ralGDS-, and CDC25-encoded proteins in the yeast two-hybrid system. Transformation was assessed in rat2 cells as well as in a mutant cell line, rv68BUR, that affords a more sensitive transformation assay. Selected mutant Ras proteins were also examined for their...

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Identifiers

PMID: 9154803
DOI: 10.1128/MCB.17.6.3047
PMCID: PMC232157

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