Article
Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells.
Molecular and cellular biology - 1 Jun 1997
Stang S, Bottorff D, Stone J C
Abstract excerpt
v-H-ras effector mutants have been assessed for transforming activity and for the ability of the encoded proteins to interact with Raf-1-, B-Raf-, byr2-, ralGDS-, and CDC25-encoded proteins in the yeast two-hybrid system. Transformation was assessed in rat2 cells as well as in a mutant cell line,...
Topics
- Animals
- Binding Sites
- Cell Cycle Proteins
- Cell Line
- Cell Transformation, Neoplastic
- GTP-Binding Proteins
- Genes, Tumor Suppressor
- Genes, ras
- In Vitro Techniques
- Mutation
- Phosphoprotein Phosphatases
- Protein Serine-Threonine Kinases