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Article

Raf-1 interferes with Ras and Rap1A effector functions in yeast.

Molecular biology of the cell - 1 Feb 1994

Ruggieri R, Macdonald S G, Callow M, McCormick F

Abstract excerpt

Raf-1 is a serine/threonine kinase that acts downstream of Ras in mitogenic signal transduction pathways, but the mechanism by which Ras transmits signals to Raf-1 is not known. We have examined the interaction between Raf-1 and human H-ras in three different systems that utilize H-ras-induced phenotypes in Saccharomyces cerevisiae. In each system, the effects of H-ras depend on guanosine triphosphate and appear...

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Identifiers

PMID: 8019003
DOI: 10.1091/mbc.5.2.173
PMCID: PMC301023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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