Article
Raf-1 interferes with Ras and Rap1A effector functions in yeast.
Molecular biology of the cell - 1 Feb 1994
Ruggieri R, Macdonald S G, Callow M, McCormick F
Abstract excerpt
Raf-1 is a serine/threonine kinase that acts downstream of Ras in mitogenic signal transduction pathways, but the mechanism by which Ras transmits signals to Raf-1 is not known. We have examined the interaction between Raf-1 and human H-ras in three different systems that utilize H-ras-induced ph...
Topics
- Cell Cycle Proteins
- Fungal Proteins
- GTP-Binding Proteins
- Genes, ras
- Guanine Nucleotide Exchange Factors
- Guanosine Triphosphate
- Humans
- Phenotype
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-raf
- Proto-Oncogene Proteins p21(ras)
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Signal Transduction
- Temperature
- Transcription Factors
- rap GTP-Binding Proteins